Immersion Liquid Nitrogen Cryo-Milling Instrument

True Liquid Nitrogen Freezing: Milled and crushed at a constant low temperature of -196℃

Professional sample pretreatment equipment, crafting micrometer-grade sample particles for you

Why choose the JXFSTPRP-MINICL Immersion Liquid Nitrogen Cryogenic Mill?

At high temperatures, certain materials (such as rubber, heavy metal elements, aromatic hydrocarbons, and food) are prone to denaturation and volatilization, while low-temperature crushing of samples does not cause temperature rise due to friction, thus preventing the loss of volatile substances and sensitive sample components. Volatile substances can be retained within an enclosed grinding vessel. Additionally, materials like bones, teeth, seeds, animal and plant tissues, and hair, which are physically tough and difficult to crush, can be effectively processed at low temperatures to perfectly preserve the structural and compositional information of the sample. Cell disruption can eliminate sample degradation, preventing the destruction of DNA and RNA.

Choosing cryogenic grinding technology as a key method for preserving the physical and chemical integrity of samples is due to the fact that at low temperatures, many samples with toughness and elasticity become more brittle, making them easier to crush, mix, and homogenize.

Comparison Chart of Grinding Effects

Liquid nitrogen cryogenic millers are widely used in product inspection and forensic identification fields.

More grinding effect comparison images available for detailed inquiries by phone.

Liquid nitrogen cryogenic millAdvantages and Features:

1. Grinding at low temperatures preserves the bioactivity of the substances, ensures the retention of volatile substances, prevents the thermal degradation of heat-sensitive compounds, and maintains the original sensitive characteristics of metabolites, isomers, and complex compounds that are sensitive to heat and mechanical pressure.

2. Sample processing is uniform and consistent, with good reproducibility.

3. The certainty after setting the grinding parameters ensures the comparability of sample processing.

4. Sample processing is convenient, quick, and efficient.

Key Performance:

1. High accuracy and reproducibility of data;

2. The sample remains in liquid nitrogen throughout the grinding process.

3. Throughout the grinding process, the samples remain in a separate, ultra-low temperature environment, preserving their integrity and preventing cross-contamination between samples, ensuring control over hazardous and critical samples.

4. Sample bottles are easy to clean and highly durable.

5. Equipped with a touch screen display, it allows for the setting and control of parameters such as pre-cooling time, grinding time, cycle duration, and the operating frequency of the hammer, as well as the entire operation process of the instrument. It can store up to 36 sets of data for convenient access.

6. Features portable design, compact size, and various grinding combinations for users with different application needs to choose from.

7. The instrument boasts high durability, reliability, and safety.

Typical Applications:

1. Nucleic Acid/Protein Extraction

Grind various animal tissues (including bones, teeth, hair, muscle, and various organs) and plant tissues (roots, stems, leaves, fruits, seeds, etc.) at liquid nitrogen temperatures, effectively inhibiting nucleic acid degradation and preserving the biological activity of enzymes. This is used for the pretreatment of extracting nucleic acids and proteins from animal and plant tissue cells.

2. Pharmaceutical Analysis and Drug Testing

Liquid nitrogen cryo-milling preserves the original biological characteristics of sensitive substances like metabolites, isomers, and complex compounds that are sensitive to heat and mechanical pressure. The complex molecules in drugs and their metabolites are crucial for pharmaceutical research or forensic experiments.

3. Medical Research

Liquid nitrogen cryogenic grinding is beginning to be widely used in medical research fields.

4、Pre-processing of special samples

For volatile substances such as coal, oil shale, wax products, and many other organic materials with low molecular weight compounds, the matrix volatilizes quickly upon grinding at room temperature. Using a liquid nitrogen cryogenic mill ensures the retention of volatile compounds, as the entire sample process is sealed within a sample bottle and milled at liquid nitrogen temperatures. Subsequent enrichment analysis can be performed by gas sweeping.

5. Plastic/Polymer Composition Analysis

Plastics, resins, textiles, and polymers are difficult to grind at room temperature but become very easy under liquid nitrogen. Additionally, it can prevent the temperature rise caused by friction during grinding from affecting the molecular structure and composition information of the sample.

6. Heavy metal testing

As countries' requirements for heavy metal content in environmental and safety aspects continue to rise, heavy metal testing has become extremely important. For many difficult-to-handle samples, such as food packaging materials, clothing, children's toys, leather, rubber, and circuit boards, using a liquid nitrogen cryogenic mill for rapid and pollution-free processing can significantly enhance the efficiency of analysis and testing.

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