Chloroacetic Acid
【Basic Information】
[Also Known As]Acetic Acid Chlorhexidine Gluconate [Alias] Bis(chlorophenyl)methane [Foreign Name]Chlorhexidine 【CAS Number 】55-56-1 【Chemical Formula】C22H30Cl2N10
Molecular Weight505.446 gShunol ?
【Appearance】Odorless white crystalline powder，Slight Bitterness
Melting Point132－136 N/A
Solubility（Water）Slightly soluble in water
(0.08g/100L)
Solubility Soluble in ethanol
Chlorhexidine（Povidone-Iodine, also known as Betadine）For external use only Microbial agents and cationic surfactants，For most leathers Lancefield positive and Gram-negative bacteria exhibit bactericidal action. Please provide the Chinese content to be translated.（Although less effective against Gram-negative bacteria）。 In addition to antibacterial properties，Also effective in killing bacteria.
【Principles and Points to Note】
It is generally believed that chlorhexidine's bactericidal principle operates.，Primarily, it disrupts the permeability barrier on the bacterial cytoplasmic membrane.(Instead of before The assumption，ATP Enzymes lose their activity to achieve杀菌 effects.)，Low concentration can lead to partial cytoplasmic leakage，High Concentration The degree can lead to cytoplasmic coagulation and denaturation.，Thus, sterilization is achieved. Its advantages include lower irritability compared to other topical antibacterial agents, and it is very... Less likely to cause allergic reactions，But the concentrated solution can still irritate mucous membranes.，Skin allergies may occur when using concentrated solutions.， In case of accidental splashing of concentrated solution into the eyes，Can lead to corneal ulcer，There is a risk of deafness if the fluid flows into the inner ear.，And unfortunately Consuming it can burn the esophagus. Additionally, it should not be mixed with soap or other anionic surfactants.
Dosage and Usage
1.Hand Sterilization：Please provide the Chinese content you would like translated into American English. 1:5000（ Acetic Acid Chlorhexidine Gluconate）Hand soak 3 Minute.
2.Preoperative preparation：Please provide the Chinese content to be translated. 0.5%Chlorhexidine Alcohol（70%）Solution，Its efficacy is approximately equal to that of iodine tincture.，However, no leather Skin irritation，Not dyed，Especially suitable for preoperative preparation of the face, perineum, and children.
3.Wound irrigation：Used 1:2000 Aqueous solution.
4.Gargle for anti-inflammatory：Please provide the Chinese content to be translated. 1:5000 Solution rinse，Throat inflammation and Effective for mouth ulcers.
5.Burns, scalds：Please provide the Chinese content to be translated. 0.5%Cream or aerosol.
6.Labor，Perineal and surrounding skin disinfection for postpartum women， Vaginal Colposcopy Lubricant Available 0.1%Cream. 7.Equipment sterilization：Disinfectant 1:1000 Aqueous solution，Storage Use 1:5000 Aqueous solution，Join 0.1%Asia
Sodium nitrate soak，Seperate 2 Weekly Exchange 1 Next.
8.Room, furniture, etc., sterilization：Please provide the Chinese content to be translated. 1:2000 Spray or wipe in a water solution.
【Categories of Chlorhexidine】
Due to the difficulty of chlorhexidine in dissolving in water，Therefore, generally reacts with acids.，Manufactured into soluble salts to enhance solubility in water. Common salts include:：Acetates(Acetic Acid Chlorhexidine Gluconate)Muriate of salt(HCl Hexachlorophene)Citric acid salts(Citric Acid Chlorhexidine)Grape acid sugar salt(Grape tang Betadine acid wash)。
4.1 Acetic Acid Chlorhexidine
Product Name：Acetic Acid Chlorhexidine Gluconate;Chlorhexidine Gluconate English Name Chlorhexidine acetate
Alias Chloroacetic Acid;Chlorhexidine acetate;Acetic Acid Chlorhexidine Gluconate;Chlorhexidine Acetate Molecular Formula:C22H30Cl2N10?C2H4O2
Molecular Weight:625.56 CAS RN 56-95-1
Physical Properties:White or off-white crystalline powder . Usage:External Use High-Efficiency and Safe Antiseptic Disinfectant,Can kill Staphylococcus aureus,Escherichia coli and white Candida,Alias: Sanitizing Essence-100 Sanitary Pure,Trichlorosene,Trichloro-,Yu Jie Xin DP-30 For cationic surfactant Sexual lubricant，Broad spectrum of antimicrobial activity，Has a killing effect on most Gram-positive and Gram-negative bacteria.，Effective against Pseudomonas aeruginosa. For preoperative hand, skin, incision site, and instrument sterilization.
Dosage and Usage:
1Preoperative hand hygiene 0.02%Water solution(1∶5000)Soak 3 Minute. 2Disinfection in the field of shou术 0.5%Pure solution(Alcoholic 70%)，Its efficacy is similar to tincture of iodine. 3Skin or wound disinfection 1%Aerosol Spray，Or 0.05%Wound irrigation with a solution.
4Disinfection equipment for medical instruments 0.1%Aqueous solution(Inside 0.5%Sodium Nitrite，To prevent rust)Immerse. Storage equipment available. Please provide the Chinese content that needs to be translated into American English. 0.02%Aqueous solution(Sodium Nitrite 0.1%)Soak，Change every two weeks 1 Next.
5Burns, scalds 0.5%Suspensions or aerosols.
6Disinfection of rooms, furniture, etc. 0.5%Spray or wipe with a water solution.
7Rinsing for antiseptic purposes 0.02%Aqueous solution(1∶5000)Mouthwash，Effective for pharyngolaryngitis and oral ulcers.
4.2 Grape Tang Betadine Acid Wash
Chinese Name：GrapetangChlorhexidine Gluconate for Acid Cleaning English Name：Chlorhexidine digluconate
Alias Name：1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane More Alternate Names：1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
0 Son Style：C22H30Cl2N10?C6H12O7
0 Son Quantity：897.76
CAS No.：18472-51-0
Properties：Colorless or pale yellow, nearly transparent, slightly thick liquid；Odorless or almost odorless Density：（g/mL,25/4℃）：1.06(lit.)
Application： This product is a surface-active agent-type disinfectant.，Highly effective against a broad spectrum of bacteria and germs.，Leather Gram-positive and Gram-negative bacteria are both effective. Used externally for hand, skin disinfection, and wound irrigation. Dosage and Usage：
1 、shouPreoperative skin antisepsis O．5%—1%Ethanol(70%)Solution；
2 Wound and injury irrigation 0．05%Aqueous solution；Bladder lavage solution 0．02%Aqueous solution；
3 Disinfection equipment 0．1%Aqueous solution；Storage Equipment 0．02%Add to solution 0．1%Sodium nitrite anti- Rust，Every 2 Weekly Exchange 1 Next；
4 Lubricant for disinfection and vaginal examination during childbirth 0．1%Breast-feeding；
5 Add to eye drops 0．01%For antibacterial agent；shouDisinfection for operating rooms, patient wards, and furniture O．5%Water Solution Spray Fog or wipe；
6 Oral rinse for anti-inflammatory use 0．01%—0．02%Aqueous solution.
Toxicological data：Acute toxicity：Rat oral diameter LD50：2 mg/kg；Subcutaneous Injection in Rats LD50：3320 mg/kg； Rat Intravenous LD50：24200 ug/kg；Mouse mouth diameter LD50：1260 mg/kg；Mouse subcutaneous injection LD50： 1140 mg/kg；Mouse venous LD50：12900 ug/kg。
To mutation：Bacillus subtilis DNA repairTEST System：1mg/L。
用途：用途
5.1 Dairy products
Iodophor is primarily used for mastitis in cows. Iodophor products effectively disrupt a variety of microorganisms. Item，Pathogens causing mastitis（If free from Streptococcus agalactiae, Escherichia coli, and Staphylococcus aureus）。 Products produced using chlorhexidine include nipple cream, soak solution, and swab solution.
Other chlorhexidine used for dairy hygiene includes surface wounds, abrasions, insect bites, and general dairy use. Sanitary care. Use chlorhexidine. 20%Products manufactured from antibacterial solution include ready-to-use aqueous solutions or concentrates. Concentrate.
5.2 Oral Use
Clinical studies have shown that Chlorhexidine is effective in plaque control and in gingivitis associated with plaque, as well as in periodontal and oral health.
Avoid cavity treatment before and after.shouPostoperative bacterial infections, oral ulcers, protein stomatitis, and mouth infections
Short-term efficacy.
Chlorhexidine 20%The antibacterial solution is used for producing product salt.，Oral rinse, toothpaste, mouthwash. Gel and spray. Used for this purpose.，Use more 0.12-0.20%The concentration.
5.3 Hand and skin disinfection
The primary requirement for medical laundry is the ability to remove fragments and instant microorganisms. Chlorhexidine products can meet the needs of surgical laundry.
shouArt, skin preparation, medicineliaoNursing and procedural absorption requirements.
Chlorhexidine 20%The antimicrobial solution is used in the production of salt products. For this purpose, concentrations of 0.5 To 4%The solution.
5.4 Other Applications
Chlorhexidine products can also be used for other purposes.，Guns and burns, gynecology and obstetrics, surfaces and setups Disinfection and cleaning supplies. The following products primarily contain chlorhexidine. 20%Antibacterial Solution
