Juncheng's traditional Chinese medicine cell wall-breaking mill can reduce the particle size of the raw material's core from the traditional process to...100~150Increase to1000As above, for general medicinal herbs, the cell wall-breaking rate under this fineness condition is greater than98%。During the crushing process, the following points should also be noted:
1. Choice of Crushing Method
A wide variety of Chinese medicinal herbs exist; we must select different grinding methods based on the texture and physical-chemical properties of the herbs, such as single herb grinding, mixed herb grinding, dry grinding, wet grinding, and low-temperature grinding.
2. Control of Fineness of Crushing
Studies indicate that the particle size range of micronized Chinese medicine is1~75Microns, within this range, the pharmacological substances in the particles will not undergo significant changes in molecular structure when compared to traditional Chinese herbal preparations and herbal formulations, thus avoiding alterations in the properties, pharmacological effects, and therapeutic indications of Chinese medicine. This ensures the stability of the pharmacological effects of Chinese medicine. During the process of Chinese medicine powdering, the average particle size is controlled at15Micron~20Approximately micrometers is ideal.
3. Enhance the microbiological quality of micro-fine powders, improve the crushing environment, and meetGMPRequirements
The rational design and operation of Jun Cheng ultra-fine grinding equipment ensure that ultra-fine pulverization of materials is carried out in a fully enclosed and purified environment, resulting in dust-free and pollution-free grinding that meets environmental protection standards. Strictly followGMPStandard design and manufacturing to meet the special requirements of powder equipment. All parts in contact with materials are polished.304Stainless steel (material can be changed according to customer requirements), effectively prevents the mixture of heavy metals such as arsenic, cadmium, lead, and copper, ensuring strong safety.
Enhance the utilization of medicinal herbs and reduce the dosage.
Using an appropriate pulverizer to process Chinese medicinal materials into superfine powder or cell wall-breaking powder, the dissolution or extraction of active ingredients is increased, enhancing the bioavailability of the drug and reducing the dosage required. For instance, Astragalus and Licorice, due to their strong fibrous nature, often leave a significant amount of residue after being ground with a regular pulverizer, leading to waste. However, using the Jun Cheng low-temperature pulverizer...15Minutes, the average particle size of the herbs can reach15Micrometers, convenient for clinical applications.
The significance of the Juncheng Traditional Chinese Medicine Cell Wall Breaking Mill in the preparation of traditional Chinese medicine formulations:
1Enhances the dissolution rate and dissolution efficiency of poorly soluble drugs.
2Enhances the dispersibility of the drug in the formulation.
3Enhances the bioavailability of the drug.
4Enhances the extraction rate of the drug.
5Improves the flowability of the medication.
6Contributes to the even distribution of each active ingredient in the compound.
7Reduce medication dosage, significantly saving raw medicinal materials.
8Enhance the compression and granulation properties of traditional Chinese medicine, ensuring pleasant taste and ease of application.
9Beneficial for the molding and preparation of various formulations.
The Jun Cheng Cell Disruption Mill has several major advantages over other types of cell disruption machines:
1Highly efficient and powerful wall-breaking, utilizing high-intensity vibration to achieve high acceleration impacts, shearing, and grinding of materials within the mill筒. This allows for ideal pulverization in a short time frame, reducing material particles to micrometer and even nanometer-sized powders. Under such pulverizing conditions, traditional Chinese medicinal materials are easily broken down at the cellular level, and are suitable for materials with fibrous, high-tensile, and high-hardness properties, with a high wall-breaking rate.。
2The application of low-temperature cell wall disruption technology, featuring a cooling closed-loop circulation system in the cell wall disruption machine's grinding chamber, equipped with a refrigeration system, breaks cell walls at low temperatures, which is beneficial for preserving the bioactive components of traditional Chinese medicinal materials. To facilitate the production of high-quality products as required. Particularly suitable for herbal materials that are fibrous, thermosensitive, or prone to deterioration when heated.
3Our fully enclosed cell wall breaking technology ensures all equipment operates in a sealed environment, with a single entry and exit for materials. Chinese herbal medicine's cell wall breaking is carried out in a sealed and purified state, maintaining high purity and preventing component segregation and loss. It effectively prevents dust issues during the production process of Chinese herbal medicine, efficiently utilizes resources, and minimizes waste.
4Non-classified cell wall-breaking technology, using a single-pass, non-classified crushing method,Material is instantly crushed upon impact, achieving a one-step powdering process. The advanced technology and process ensure precise blending (dispersion and emulsification) during crushing, with ease of operation.
5Physical cell disruption technology, utilizing high-frequency vibration, impact shearing, friction, and compression to break the cell walls of traditional Chinese medicine without causing a chemical reaction, preserving the original chemical properties of the material.
6Sanitation and safety technology: Strictly in accordance withGMPStandard design and manufacturing to meet the special requirements of powder equipment. All parts in contact with materials are polished.304Stainless steel (material can be customized to customer's requirement), effectively prevents the mixture of heavy metals like arsenic, cadmium, lead, and copper, ensuring strong safety.
